Operating on the potentials of the local communities have fundamental role in the development and modification of relevant internal disparities. In spite of being the the pole of mineral reserves in the country, South Khorasan province  with its large  mineral deposits –– has little share in the resulting economic development or the impowerments which may have been caused by it. In this paper,  a suitable guides for regional development in framework of strategic programming is proposed. This descriptive - analytic study attempts to identiry the effective factors in the development of industry & mining  through the analysis of the strengths, weaknesses, opportunities and threats (SWOT). For the purpose of the study, government policies  were examined through 65 questionnaires distributed among the relevant public authorities and academics.  Based on the SWOT model, strategies were then analyzed in the QSPM matrixin order to prioritize  stages of execution.  Results showed that  opportunities such as the shared border with Afghanistan with  the possibility of exporting industrial products, the distinctive prospect of creating the economic balance in the eastern regions of the country, availability of metalic and non-metallic mineral reserves, existence of towns and industrial zones in the province for the establishment of industrial units, and the possibility of agriculture with certain crops creates major capacities for programmed advances in the mining industry in South Khorasan province. Meanwhile, Lack of large industries and mining in the province, Lower productivity of labor, lack of capital, Water limitations and problems in the economic policies  are the major obstacles to the development of the mining industry in South Khorasan province. Overall, the results formulate the plethora of weaknesses in the mining industry in South Khorasan.South Khorasan  Henceforth, improvement strategies are presented in form of suggestion in the areas of necessary infrastructures, environmental considerations, mobility and transport systems, and demand-related distribution of capital.